Cutting Edge: Influenza-Induced CD11alo Airway CD103+ Tissue Resident Memory T Cells Exhibit Compromised IFN-γ Production after In Vivo TCR Stimulation
Airway and vasccular labeling identifies compartmentalized influenza TRM.
CD11alo airway TRM exhibit reduced IFN-γ after in vitro peptide stimulation.
CD11alo airway TRM produce minimal IFN-γ or CD25 after in vivo stimulation.
CLINICAL AND HUMAN IMMUNOLOGY
Nitroso dapsone–modified HLA binding peptides activate human CD8+ T cells.
T cell activation was restricted to HLA-B*13:01.
IFN1 Enhances Thrombocyte Phagocytosis through IFN Receptor Complex-JAK/STAT-Complement C3.3-CR1 Pathway and Facilitates Antibacterial Immune Regulation in Teleost
IFN1 enhances phagocytosis via the IFN receptor complex-JAK/STAT-C3.3-CR1 pathway.
The complements can aggregate bacteria in teleost.
IFN1 demonstrates effective antibacterial activity at physiological status.
Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4
IL-9R is highly upregulated on mouse TRAF3-deficient B lymphocytes.
IL-9 enhances CSR induced by BCR crosslinking plus IL-4 in TRAF3-deficient B cells.
JAK or STAT3 inhibitors abrogate the enhancing effect of IL-9 on CSR.
INFECTIOUS DISEASE AND HOST RESPONSE
Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape
IAV-derived AM58–66GL9-paralleled peptide in IBV is an HLA-B*1501 T cell epitope.
BM58–66AF9 is presented in a similar featureless conformation as AM58–66GL9.
The sequence around BM58–66AF9 epitope does not overlap with an NES.
Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid–Binding Protein 4–Dependent White Adipose Tissue Pathology
C. pneumoniae lung infection causes lipolysis in WAT in a FABP4-dependent manner.
Infection-induced FABP4 secretion augments ER stress and promotes M1-like ATMs.
The presence of FABP4 either in adipocytes or ATMs is required to induce WAT pathology.
INNATE IMMUNITY AND INFLAMMATION
cGAS promotes the macrophage phenotype switch to the M1 phenotype via the mTORC1 pathway.
cGAS is activated by mtDNA and further acts as a polarization switch in inflammation.
Deletion of Cgas significantly ameliorates sepsis-induced acute lung injury.
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production
Ablating FcRγ or PLZF from expanded primary human NK cells does not affect ADCC.
Ablating SYK increases ADCC in NK cells whereas ablating ZAP70 decreases ADCC.
The enhanced function of SYK-ablated cells is retained up to 27 d post-CRISPR.
NF-κB–Inducing Kinase Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells
NIK-deficient macrophages exhibit impaired mitochondrial oxidative phosphorylation.
NIK-deficient mice have more inflammatory myeloid cells in blood and bone marrow.
NIK-dependent metabolic rewiring shapes pro- and anti-inflammatory innate immunity.
Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA Class I Molecules in Endothelial Cells: Role of YAP Multisite Phosphorylation
Statins induced cytoplasmic YAP localization and inhibited its activity in human ECs.
Mevalonic acid or geranylgeraniol reversed the inhibitory effect of statins on YAP.
Statins inhibit YAP Tyr357 phosphorylation, which is critical for YAP activation.
DC2 limit initial metastatic burden in the lung.
In response to tumor-derived nucleic acids, DC2 produce host-required IL-12p40.
Local DC2 and NK cells coordinate initial metastatic control.
NOVEL IMMUNOLOGICAL METHODS
Quality and stability of fluorescent ligand tetramers can vary from batch to batch.
Ligand tetramers can be sensitively assessed using Abs bound to beads.
A Real-Time Image-Based Efferocytosis Assay for the Discovery of Functionally Inhibitory Anti-MerTK Antibodies
A novel real-time and quantitative image-based efferocytosis assay was established.
Removal of cell debris in the meal resulted in relatively specific efferocytosis.
The new method is applicable to both basic research and drug discovery.
On the cover: Three-dimensional rendering of surface interactions of disseminated tumor cells (green) surrounded by CD11c+ cells (white) and NK1.1+ cells (red) from early metastatic-bearing lung cells of wild type mice. Weizman, O.-E., S. Luyten, I. Krykbaeva, E. Song, T. Mao, M. Bosenberg, and A. Iwasaki. 2023. Type 2 dendritic cells orchestrate a local immune circuit to confer antimetastatic immunity. J. Immunol. 210: 1146–1155.
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