PILLARS OF IMMUNOLOGY
Memory CD4 T Cell Distribution and Recall Function in Nonlymphoid Organs
Immunomodulatory Effects of Microbiota-Derived Short-Chain Fatty Acids in Autoimmune Liver Diseases
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging
Constitutively active gp130 in T cells leads to senescence-associated inflammaging.
The JAK/STAT axis is crucial for the development of autoimmunity and thrombocytosis.
The reported mouse line might be used as a model for cellular senescence.
Cooperative but Distinct Role of Medullary Thymic Epithelial Cells and Dendritic Cells in the Production of Regulatory T Cells in the Thymus
Depletion of mTECs affected the Treg production more strongly than that of DCs.
mTECs, not the cTECs, are the main source of self-Ags transferred from TECs to DCs.
IL-2 produced by recirculating non-Tregs is required for thymic Treg expansion.
Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration and Th17 Pathogenicity
CD4 T cell–intrinsic STAT4 expression controls migration to the CNS during EAE.
STAT4 is required for Th17 pathogenicity independent of IL-17A production.
Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction
hNSCs induce CD25+Foxp3+ Tregs from conventional T cells.
This conversion to Tregs is driven by hNSC Ags and not secreted factors.
hNSC Ags require thymic presentation for peripheral Treg conversion.
CLINICAL AND HUMAN IMMUNOLOGY
Distinctive Dynamics and Functions of the CD4+CD25+FOXP3+ Regulatory T Cell Population in Patients with Severe and Mild COVID-19
TREG population is expanded in severe COVID-19 patients with enhanced apoptosis.
TREG suppressive function is not altered in patients with severe or mild COVID-19.
TREG frequency inversely correlates with T cell function in mild COVID-19 patients.
Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity
Human CCR6+ Th cells lie along an extended, stable continuum of type 17 character.
Type 17 cells show not only environment-inducible but also imprinted plasticity.
Human Th cells with a history of early multilineage activation persist as memory.
Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation
Persistent gp130 signaling in T cells causes a bias to TH17 cell differentiation.
Transgenic mice with continuously active gp130 in T cells develop lung inflammation.
IMMUNE SYSTEM DEVELOPMENT
The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells
The major S/T phosphorylation on Bcl11b is dispensable for T cell development.
The phosphorylation may regulate Bcl11b protein stability.
Natural Microbial Exposure from the Earliest Natural Time Point Enhances Immune Development by Expanding Immune Cell Progenitors and Mature Immune Cells
Natural microbial exposure expands immune cell progenitors in neonatal mice.
Natural microbial exposure broadly expands mature immune cells in young mice.
Natural microbial exposure enhances early-life host defense.
IMMUNOTHERAPY AND VACCINES
The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1
Mll1 is a positive regulator of TFH differentiation.
Mll1 regulates expression of LEF-1, TCF-1, and Bcl6.
INFECTIOUS DISEASE AND HOST RESPONSE
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS–STING Pathway
B. burgdorferi triggers type I IFN responses in macrophages and fibroblasts.
Coiled spirochetes are observed in the cytosol and colocalize with cGAS.
cGAS and STING mediate B. burgdorferi–induced type I IFN responses.
INNATE IMMUNITY AND INFLAMMATION
Transcriptional Regulation and Signaling of Type IV IFN with Identification of the ISG Repertoire in an Amphibian Model, Xenopus laevis
IFN-υ can be activated by IRF1, IRF3, IRF7, and p65.
The ISG repertoire contains major expanded families of AMNTR, GVIN, GBP, RTP, and IFIT.
AMNTR50 negatively regulates the expression of type I, III, and IV IFNs.
IL-18 Binding Protein–Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome
Neutrophils, macrophages, endothelial cells, and erythroid precursors produce IL-18BP.
IL-18 indirectly impairs erythropoiesis while favoring myelopoiesis.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1
High expression of APE1 and APE2 early after activation promote CSR.
After initial activation, APE1 protein dilutes out with cell division.
APE2 remains highly expressed and promotes SHM that is suppressed by APE1.
MHC Class I Ligands of Rhesus Macaque Killer Cell Ig-like Receptors
MHC class I ligands were identified for 12 rhesus macaque KIRs.
Rhesus macaque KIRs interact with three general categories of MHC class I ligands.
Novel KIR interactions were identified with Mamu-AG, -B*045, and -A1*012.
NOVEL IMMUNOLOGICAL METHODS
Identification and Characterization of Alveolar and Recruited Lung Macrophages during Acute Lung Inflammation
We developed, to our knowledge, a novel technique to specifically identify macrophage subsets in lungs.
We used this method to characterized macrophage phenotypes during lung inflammation.
Development of C1q Affinity Chromatography for the Study of C1q–IgG Interactions
Development of a novel HPLC method for studying C1q–ligand interactions.
scC1q column binding correlates with biological activity of anti-CD20 IgG isotypes.
On the cover: Representative tissue sections of the intestine of a 12-wk-old Lgp130 × CD4Cre mouse. These mice express a constitutively active IL-6R gp130 chain in all conventional T cells (H&E). Heinig, L. C., E. V. M. Huth, K. Yan, N. Schumacher, M. Nawrocki, N. C. Lory, P. Bradtke, T. Bertram, G. Rattay, J. Schmid, S. Huber, T. Wiech, D. Schmidt-Arras, S. Rose-John, and H.-W. Mittrücker. 2023. Cell-autonomous constitutive gp130 signaling in T cells amplifies TH17 cell responses and causes severe lung inflammation. J. Immunol. 210: 1717–1727.
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